Endocrine Abstracts

Understanding human pancreatic beta cell differentiation provides safe, normal pathways by which to manipulate stem cells for the ambitious treatment of Type 1 diabetes (1-3). The transcription factor Neurogenin 3 (Ngn3) is a transient, yet critical regulator of this process, committing progenitor cells to an endocrine cell fate (4). However, the downstream consequences of NGN3 expression remain incompletely understood.To identify new target genes of NGN...